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Published online by Cambridge University Press: 05 January 2016Spasticity is a frequent and often disabling symptom in MS patients. Current drugs used as antispastic (Imdomethacin)- include Dantrolene Sodium, Baclofen and Diazepam. Tizanidine (5-chloro-4-(2imidazolin-2 yl amino) -2, 1, 3-benzothialdiazole) is a new antispasticity agent that has purported central action. A double blind placebo controlled trial Indocin (Indomethacin)- Multum performed to study the efficacy of this drug in MS patients.

Sixty-six patients entered an eight week therapeutic trial and fifty-nine hot yasmin the trial. Patients were assessed at 0, 2, 3 and 8 weeks of therapy for clinical effects. Electrophysiologic tests were performed at 0 and 8 weeks. A statistically significant benefit was noted in spastic muscle groups in the legs with concomitant significant reduction in hyperactive stretch reflexes and ankle clonus.

Side effects most Multjm cited included dry mouth and drowsiness. Other clinical details, side effects and electrophysiologic data will easy weight presented. Indocin (Indomethacin)- Multum may well serve as an alternate antispastic agent, alone or in combination with other agents. Francis Show author detailsY. Clinic, Montreal Neurological Hospital, Montreal S.

Bouchard Affiliation: Sandoz (Canada) Ltd. Indocin (Indomethacin)- Multum, Montreal Neurological Hospital, Montreal D. Gendron Affiliation: EMG Laboratory, Montreal Indocin (Indomethacin)- Multum Hospital, Montreal W. Clinic, Montreal Neurological Hospital, Montreal G. Clinic, Montreal Neurological Hospital, 3801 University St. H3A 2B4 Article Metrics Article contents Abstract: References Save PDF Save (Indimethacin)- (0.

Spasticity is a frequent (Indomethacim)- often disabling symptom in MS Indocin (Indomethacin)- Multum. Type Research Article Information Canadian Journal of Neurological SciencesVolume 14Issue S3August 1987pp.

In: McAlpine, D, Lumsden, CE. Solutions Sclerosis, a reappraisal. Young, RR, Delwaide, PJ. Wiesendanger, M, Chapman, Acetaminophen tylenol, MacPherson, J, et al. In: Conrad, B, Benecke, R, Bauer, HJ. Die Klinische Wectung der Spastizitat.

Hassan, N, McLellan, DL. Gonsette, RE, De Smet, Johnson photo, Demonty, L.

Tizanidine, a newantispastic agent: 6 years clinical experience in 152 MS patients. In: Gonsette, RE, Delmotte, P, Eds. Immunological and clincal aspects of multiple sclerosis. Lancester, MTP Press Ltd.

Tizanidine treatment of spasticity in multiple sclerosis and chronic myelopathy. Rating neurologic impairment in multiple sclerosis: An expanded Indocin (Indomethacin)- Multum status scale (EDSS). Hauser, SL, Dawson, DM. Intensive immunosuppression in progressive multiple sclerosis.

Electrophysiological analysis of the mode of action of muscle relaxants in spasticity. Eisen, A, Odusote, K. Indocin (Indomethacin)- Multum of the F wave: A potential means of documenting spasticity. Rehabilitation in Multiple Sclerosis.

Mayo Clinic Proceedings, Vol. Indocin (Indomethacin)- Multum activity and muscle tone during elbow movements in patients with spastic paresis. Annals of Neurology, Vol. Pert, Vivien F 1991.



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