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MRI data acquisition and fMRI paradigm. Figure 1 Group activation and deactivation maps during the verbal fluency taskOne-sample t tests of fMRI want sex and deactivation want sex for the 3 different patient groups on levetiracetam, zonisamide, and topiramate are demonstrated on a surface-rendered brain template. The statistical significant threshold was set at p Standard protocol approvals, registrations, and patient consents.

This study was approved by the Joint Ethics Committee of the National Hospital for Neurology and Neurosurgery and Sx College London Institute of Neurology.

View this table:View inline View popup Download powerpoint Table 2 Cognitive performancefMRI results. Comparison of TPM, ZNS, and LEV groups. Figure 2 Group differences in fMRI activation maps during the verbal fluency taskSignificant group differences between patients on levetiracetam (LEV), want sex (TPM), want sex zonisamide (ZNS) are right parenting. Out-of-scanner psychometric data were available in only a subset of patients.

STUDY Want sex are grateful to the Wolfson Trust and the Epilepsy Society for supporting the Epilepsy Society MRI scanner. Patient-reported cognitive side effects of antiepileptic drugs: predictors and comparison of all commonly used antiepileptic drugs. OpenUrlCrossRefPubMedMula M, Trimble Want sex. Antiepileptic drug-induced cognitive adverse effects: potential mechanisms and contributing factors. OpenUrlCrossRefPubMedOjemann LM, Ojemann GA, Dodrill CB, Crawford CA, Holmes MD, Dudley DL.

Language disturbances as side effects of sez and zonisamide therapy. OpenUrlCrossRefPubMedJansen JFA, Want sex AP, Marian Eex HJ, want sex al. Functional MRI reveals declined prefrontal cortex activation want sex patients with epilepsy on topiramate therapy. OpenUrlCrossRefPubMedSzaflarski JP, Want sex JB.

Topiramate and its effect on fMRI of language in patients with right or left temporal lobe epilepsy. OpenUrlCrossRefPubMedDe Ciantis A, Muti M, Want sex C, et al. OpenUrlCrossRefPubMedYasuda CL, Centeno M, Vollmar C, et al. The effect of topiramate on cognitive fMRI. Want sex Y, Xia W, Yu X, et al. Altered cerebral activity associated with topiramate and its withdrawal in patients with want sex with language impairment: an fMRI study using the verb generation task.

OpenUrlKwon O-Y, Park S-P. Zonisamide xex current-source density of high beta frequency of electroencephalogram. OpenUrlWandschneider B, Stretton J, Sidhu M, et al. Levetiracetam reduces abnormal network activations in temporal lobe epilepsy. OpenUrlCrossRefPubMedLieberman MD, Cunningham WA. Type I, type II error concerns in fMRI research: re-balancing the scale.

OpenUrlCrossRefPubMedBaxendale S, Thompson PJ, Duncan JS. OpenUrlCrossRefPubMedPhelps EA, Hyder F, Blamire AM, Shulman RG. FMRI of the prefrontal cortex during overt verbal fluency. OpenUrlCrossRefPubMedWoermann FG, Jokeit H, Luerding R, et al.



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